0704-883-0675     |      dataprojectng@gmail.com

TOXICOLOGICAL ASSESSMENT OF THE METHANOL LEAF EXTRACT OF SECURINEGA VIROSA(ROXB EX. WILLD) IN WISTAR RATS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 5000

ABSTRACT

Securinega virosa is one of the African medicinal plants described as a true “cure all” among traditional practitioners. Different parts of Securinega virosa have been used in the management of different disorders in Nigeria and other parts of the world. There is therefore the need to establish the toxicity profile of Securinega virosa leaves. In this study, toxicological assessment of the methanol leaf extract of Securinega virosa was carried out in Wistar rats. Forty rats of either sex (20 males and 20 females) were divided into four groups of 10 rats (5 males and 5 females) each and kept in separate cages. The rats were administered with 250, 500 and 1000 mg/kg body weight of the extract daily for 28 days. The effect of the extract on body weight, haematolological and biochemical (renal function, liver function and lipid profile) parameters as well as histopathological studies of the organs (liver, kidney, spleen, lungs, brain, heart, stomach, uterus, ovaries and testes) was assessed. The oral and the intraperitoneal median lethal dose (LD50) values of the extract were estimated to be greater than 5000 mg/kg bodyweight and within the doses of the study, no mortality was observed in both acute and sub-acute toxicity studies. The extract had no significant (p˃0.05) effect on body weight. The haematological parameters measured were normal except a significant (p˃0.05) increase in platelets count observed at the dose of 1000 mg/kg body weight. There was a significant (p˃0.05) increase in liver biomarkers, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase in both male and female rats treated at doses of 500 and 1000 mg/kg body weight when compared with the control. There was also a significant (p˃0.05) increase in the serum urea and creatinine in these groups. Histopathological findings indicated that there were some levels of liver damage vi characterised by centrilobular necrosis peri-portal hepatocytic vacuolation and scattered inflammatory changes, kidney (glomerular damage and atrophy, tubular epithelial cell necrosis and vascular congestion), and brain (degeneration of nerve fibres, pyknosis and vacuolation) at doses of 500 and 1000 mg/kg body weight. Some levels of damage was also observed in the spleen (splenic congestion) and lungs (diffused areas of congestion and inflammation) of both male and female rats across all the doses administered. These findings suggest that the methanol leaf extract of Securinega virosa is practically non toxic following acute administration, however, it produced some levels of damage to the liver, kidney, heart, spleen, lungs and brain in Wistar rats following oral administration for 28 days




FIND OTHER RELATED TOPICS


Related Project Materials

An Examination of the Role of Government Policies in Promoting Sustainable Agriculture in Nigeria

Background of the Study
Government policies play a pivotal role in shaping the direction and sustainabilit...

Read more
The Effect of Local Government Fiscal Policies on Revenue Generation in Nguru Local Government, Yobe State

Chapter One: Introduction

1.1 Background of the Study

Nguru Local Government in Yobe State, located in northeastern Nigeria, ha...

Read more
ENVIRONMENTAL EFFECTS OF THE USE OF AGRO- CHEMICALS FOR RICE CULTIVATION IN UFUMA, ORUMBA NORTH LOCAL GOVERNMENT AREA; ANAMBRA STATE

ABSTRACT

The study delved into the effect of the use of agrochemical in rice farming using Ufuma, Orumb...

Read more
An Examination of the Challenges of Environmental Auditing in Nigeria: A Study of the Cement Manufacturing Industry

Background of the Study

Environmental auditing is a critical process for assessing compliance with environmental regulat...

Read more
ANALYSIS OF URBAN LAND USE PLANNING IN MINNA, NIGERIA

ABSTRACT

Housing is a basic need of every human being just as food and clothing. Density simply refers to how much of a particular object...

Read more
The Effect of Urbanization on the Prevalence of Non-Communicable Diseases in Yobe State

Background of the Study

Urbanization is a global phenomenon that has led to significant changes in lifestyle, environmental conditions, a...

Read more
A Critical Analysis of Big Data Applications in Fraud Detection in Nigerian Commercial Banks: A Study of Microfinance Institutions in Gombe State

Background of the Study

Big data refers to the massive volume of structured and unstructured data that...

Read more
An assessment of contraceptive use and birth spacing among women in Kano State

Background of the Study:

Contraceptive use and birth spacing are critical components in the promotion of reproductive he...

Read more
An evaluation of the effectiveness of teacher-student collaboration in improving physical education outcomes in Lafia Local Government Area, Nasarawa State.

Background of the Study
Teacher-student collaboration is a dynamic process that can significantly enhance the learning env...

Read more
Enhancing Network Efficiency through Protocol Optimization in Federal University, Dutsin-Ma, Katsina State

Background of the Study
In academic institutions like Federal University, Dutsin-Ma, Katsina State, network efficiency is c...

Read more
Share this page with your friends




whatsapp